Microbial conversion of anthracycline antibiotics. III. Glycosidation of natural and chemically synthesized anthracycline aglycones.
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چکیده
منابع مشابه
Microbial conversion of anthracycline antibiotics. I. Microbial conversion of aclacinomycin B to aclacinomycin A.
Streptomyces galilaeus OBB-111 and its blocked mutant were found to convert aclacinomycin B and related anthracycline glycosides of the B type to the corresponding A-type glycosides. Only the cell fraction of cultures of S. galilaeus OBB-111 was capable of catalyzing the reaction. The activity was associated with growth but disappeared before the start of rapid production of aclacinomycins A an...
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Previous fluorescence microscopic studies have shown daunorubicin (DNR) and Adriamycin (ADR) are localized in cell nuclei, whereas trifluoroacetyladriamycin-14-valerate is local ized in the cytoplasm. Using cultured cells, we correlated structural characteristics of a series of anthracycline antibiotics with cellular disposition and metabolic response. When ob served under fluorescence microsco...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1984
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.37.1469